The character premiered in E-Man #1, the first of ten issues (Oct. 1973 - Sept. 1975) published by the Derby, Connecticut-based Charlton Comics. For the last four, artist Staton created painted covers, a comics rarity at the time. The stories were humorous and lighthearted, in the style of Plastic Man, especially as E-Man could form himself into anything he wanted. by Joe Staton.Backup features were Cuti and Tom Sutton's "The Knight", starring a superspy agent of C.H.E.S.S.; Joe Gill and Steve Ditko's "Liberty Belle"; two stories of writer-artist Ditko's superhero "Killjoy"; the time-traveling "Travis", by Cuti and Wayne Howard; and, in the color-comics debut of John Byrne, three stories of "Rog-2000", written by Cuti and starring a wiseacre, cigar-smoking robot Byrne had created in his fan-artist days.

A supporting character, the grubby but right-hearted detective Mike Mauser, got his own backup series in Charlton's Vengeance Squad. An additional E-Man story, which introduced his energy-being "sister", Vamfire, appeared in the company's in-house fan magazine, Charlton Bullseye #4.

In 1977, six issues were reprinted under the Modern Comics label for sale as bagged sets in discount department stores such as North America. 

 Later Publications

Several years after the cancellation of the First Comics series, Comico published an E-Man one-shot (Sept. 1989) by Cuti & Staton, followed by a three-issue miniseries (Jan.-March 1990). After Comico's demise, Alpha Productions did a one-shot in (Sept. 1993), as well as three ashcan previews of that issue.

E-Man appeared in the two-page story "Come and Grow Old With Me", by Cuti and Staton, published in the magazine Comic Book Artist #12 (March 2001).

Cuti & Station reteamed for two one-shots by Digital Webbing Press published the one-shots E-Man: Recharged (Oct. 2006) and E-Man: Dolly (Sept. 2007), each with Cuti & Staton as the creative team.^[1] The indicia for each listed E-Man as copyrighted by "Joe Staton/First Comics".

A previously unpublished E-Man story (done originally for Alpha Productions) by Cuti & Staton, saw print in Charlton Spotlight #6 (2008), along with an unpublished Mike Mauser story.